Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient
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چکیده
منابع مشابه
Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient
This mini-review provides the entire experimental history of the development of the old neuroleptic thioridazine (TZ) for therapy of antibiotic resistant pulmonary tuberculosis infections. TZ is effective when used in combination with antibiotics to which the initial Mycobacterium tuberculosis was resistant. Under proper cardiac evaluation procedures, the use of TZ is safe and does not produce ...
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IZINDABA 318 A top-level think tank on KwaZulu-Natal's perplexing 'outbreak' of XDR-TB has recommended urgent inpatient point prevalence surveys and better screening of HIV-positive TB-symptomatic patients in order to better assess its country-wide extent. Speaking after provincial health, World Health Association (WHO) and Medical Research Council (MRC) officials met in Pietermaritzburg at the...
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Globally, tuberculosis infections continue to increase their resistance to antibiotics. Multidrug resistant tuberculosis infections (MDR TB) have progressed to extensively drug resistance status (XDR TB) and the latter have evolved in some parts of the world to totally drug resistant (TDR TB) infections. MDR TB is difficult to treat successfully, and when therapy is ineffective, a single case c...
متن کاملThe Anticancer Activity of the Old Neuroleptic Phenothiazine-type Drug Thioridazine.
Thioridazine (TZ), an antipsychotic drug, renders multidrug-resistant (MDR) cancer cells susceptible to cytotoxic agents to which they were initially resistant, has anti-prolilferative activity and apoptosis-inducing properties in various tumor cell lines and cancer stem cells. Whereas the anti-proliferative activity takes place at high concentrations that ensure the intercalation of the compou...
متن کاملOrigin of the term XDR-TB.
Diagnosis of Heli-cobacter infection with a new non-invasive antigen-based assay. HpSA European study group. MIGLIORI et al. [1] have written a commendable editorial about the challenges to science presented by the emergence of extensively drug-resistant tuberculosis (XDR-TB) as a named entity. We wish to clarify the origin and development of the term ''XDR-TB''. As noted by MIGLIORI et al. [1]...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2012
ISSN: 1424-8247
DOI: 10.3390/ph5091021